To produce the pharmaceutical dosage forms via hot-melt granulation, a pharmaceutical grade polymer must be selected that can be processed at a relatively low temperature due to the thermal sensitivity of most drugs. Melt granulation is a process by which pharmaceutical powders gets converted to granules form by the use of a binder which can be a molten liquid, a solid or a solid that melts during the process. For accomplishing this process, the apparatus of choice comprises of high-shear mixers, Rapid mixer and granulator etc. where the product temperature is raised above the melting point of the binder either by a heating jacket. More recently, this work also describes a hot melt granulation technique to improve the dissolution characteristics of a poorly water-soluble drug and sustained release property. Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable binder. The advantage of this technique compared to conventional granulation is that no water or organic solvents are needed. Because there is no drying step, the process is less time consuming and uses less energy than wet granulation.
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